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What are the effects of combining Wellbutrin-450 mg Prozac-10mg Depakote-1000mg Xanax-.5mg and Klonopin-.5mg daily?

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It should be fine. Wellbutrin is commonly combined with ssri's like prozac to augment them in the case of treatment resistant depression, and depakote xanax and klonopin all affect a different neurotransmitter system. I was on wellbutrin 300 mg, lexapro (an ssri) 10 mg and depakote at one point and was fine. Check with your doctor and check in a drug interaction checker like on webmd. But it seems redunant and possibley dangerous combining xanax and klonopin as they are both in the same drug class and depakote effects the same neurotransmitter system, GABA, as xanax and klonopin. Especially at the 1000mg dose it doesn't seem like the xanax and klonopin are needed. Too much GABA activity can cause brain damage and lower your blood pressure to dangerous lows possibley causing death. Again check with your doctor.

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